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HIF1{alpha}-{beta}-catenin inhibits MMP13 and osteoathritis [Systems Biology]

PNAS Early Edition Articles - Wed, 04/27/2016 - 14:24
Low oxygen tension (hypoxia) regulates chondrocyte differentiation and metabolism. Hypoxia-inducible factor 1α (HIF1α) is a crucial hypoxic factor for chondrocyte growth and survival during development. The major metalloproteinase matrix metalloproteinase 13 (MMP13) is also associated with chondrocyte hypertrophy in adult articular cartilage, the lack of which protects from cartilage degradation...

Astrocytic control of cortical state switching [Neuroscience]

PNAS Early Edition Articles - Wed, 04/27/2016 - 14:24
The role of astrocytes in neuronal function has received increasing recognition, but disagreement remains about their function at the circuit level. Here we use in vivo two-photon calcium imaging of neocortical astrocytes while monitoring the activity state of the local neuronal circuit electrophysiologically and optically. We find that astrocytic calcium...

Bjorn Lomborg on UN climate deal: ‘This is likely to be among most expensive treaties in the history of the world’

Climate Depot - Wed, 04/27/2016 - 14:23
http://www.usatoday.com/story/opinion/2016/04/21/climate-change-real-paris-treaty-costly-few-benefits-research-green-energy-column/83292440/   Lomborg Skewers Pact’s Horrific Costs for Mere 0.086 Degrees Fahrenheit Bjorn Lomborg, the Danish author, environmentalist, and professor of political science and philosophy, says “Politicians will vaunt U.N. treaty, but its costs far outweigh its meager benefits.” In an op-ed today for USA Today, entitled “Climate change is real, but Paris treaty won’t fix [...]

U.S. Signs UN Climate Pact Blasted as Disastrous by Scientific, Economic Experts

Climate Depot - Wed, 04/27/2016 - 14:12
  Weather Channel Founder: It’s all Politics, not Science Not surprisingly, the establishment corporate media have provided full-throated support for the Earth Day extravaganza at the UN. That’s par for the course; they have been marching in lock-step on this issue, as shills for the globalist agenda, for years now. The USA Todayeditorial board, for [...]

BBC: Rise in CO2 has ‘greened Planet Earth’ – ‘Plant boom’

Climate Depot - Wed, 04/27/2016 - 14:05
The new study is published in the journal Nature Climate Change by a team of 32 authors from 24 institutions in eight countries. Carbon dioxide emissions from industrial society have driven a huge growth in trees and other plants. A new study says that if the extra green leaves prompted by rising CO2 levels were [...]

Watch: Morano on Fox on failed green energy stimulus: ‘This could be Solyndra 2 — The Heretic!’

Climate Depot - Wed, 04/27/2016 - 09:17
‘Risk and Reward with Deirdre Bolton’ – Fox Business – April 22, 2016

Suspended Bell Bend project clears environmental review

World Nuclear News - Wed, 04/27/2016 - 08:11
Environmental impacts would not prevent the issuance of a licence to build and operate the proposed Bell Bend nuclear power plant in Pennsylvania, the US Nuclear Regulatory Commission and the Army Corps of Engineers have concluded. However, other reviews in the licensing process for the project have been suspended.

Report: NSIDC ‘deleted a lot of older Arctic ice when they switched maps’

Climate Depot - Tue, 04/26/2016 - 13:35
NSIDC deleted almost half of the five year old ice when they switched to the new maps. They also deleted about a third of the four year old ice, and some of the three year old ice. … Besides deleting data, NSIDC also deleted a lot of older ice when they switched maps. Note inside [...]

A Few Facts For Climate Alarmists Waging War Against Astrophysicist Dr. Willie Soon

Climate Depot - Tue, 04/26/2016 - 11:54
In February of 2015, Greenpeace agent Kert Davies, a vocal critic since 1997, falsely accused Dr. Soon of wrongfully taking fossil-fuel company grants by failing to disclose “conflicts of interest” to an academic journal. The journal’s editors and the Smithsonian Institution found no violation of their disclosure or conflict of interest rules. However, the Greenpeace [...]

John Kerry Signs UN Climate Deal With Granddaughter Seated in His Lap

Climate Depot - Tue, 04/26/2016 - 11:30
In a symbolic photo opportunity designed to remind the public of its duty to protect the health of future generations, Secretary of State John Kerry brought his young granddaughter with him to the United Nations as he signed an international commitment to curb the pace of global warming. Over 150 nations are expected to sign [...]

Big Green’s out-sized influence over free speech

Climate Depot - Tue, 04/26/2016 - 10:48
If you’ve ever wondered why there is a paucity of skeptical global warming articles from mainstream media outlets, journalist Matt Ridley explains why in his eye-opening OP-ED published today in The Times. He begins by describinghow last week, The Times’ editor received a letter from several readers who were unhappy with two articles written by [...]

Validation is missed in models [Letters (Online Only)]

PNAS Early Edition Articles - Tue, 04/26/2016 - 10:42
Many new studies have been published supporting the hypothesis that the Atlantic Meridional Overturning Circulation (AMOC) is experiencing a slowdown. These studies are based on proxies, climate model predictions, or a combination of both. The latest work (1) is only based on predictions. The AMOC is allegedly slowing down at...

‘Climate Hustle helps thinking people see past the fear mongering of the current climate narrative’ – In theaters on May 2 One Night Only

Climate Depot - Tue, 04/26/2016 - 10:36
Marc Morano, the documentary’s host, opens by stating: “We repeatedly hear that the time for debate is past” and then addresses the oft-quoted “97 out 100 scientists agree that climate change is real” narrative. Climate Hustle then crushes both claims—and many more (including whether or not CO2 is “the villain”). Using a touch of humor [...]

Robust AMOC-IV response to warming [Letters (Online Only)]

PNAS Early Edition Articles - Tue, 04/26/2016 - 10:32
Based on 19 experiments using five models of the Coupled Model Intercomparison Project Phase 5, our study (1) finds a shortened and weakened interdecadal variability (IV) of Atlantic Meridional Overturning Circulation (AMOC) over a future intense warming period in the 22nd and 23rd centuries, and proposes that warming-induced changes of...

US producers call for suspension of federal inventory transfers

World Nuclear News - Tue, 04/26/2016 - 09:57
An organization representing US uranium producers has called on the Department of Energy (DOE) to cease transfers of excess uranium from federal inventory until the uranium market recovers from its current oversupplied state.

DDX3 inhibitors as broad spectrum antivirals [Medical Sciences]

PNAS Early Edition Articles - Tue, 04/26/2016 - 09:55
Targeting a host factor essential for the replication of different viruses but not for the cells offers a higher genetic barrier to the development of resistance, may simplify therapy regimens for coinfections, and facilitates management of emerging viral diseases. DEAD-box polypeptide 3 (DDX3) is a human host factor required for...

Histamine H1 receptors and memory retrieval [Neuroscience]

PNAS Early Edition Articles - Tue, 04/26/2016 - 09:55
Retrieval represents a dynamic process that may require neuromodulatory signaling. Here, we report that the integrity of the brain histaminergic system is necessary for retrieval of inhibitory avoidance (IA) memory, because rats depleted of histamine through lateral ventricle injections of α-fluoromethylhistidine (a-FMHis), a suicide inhibitor of histidine decarboxylase, displayed impaired...
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