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Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing [Neuroscience]

PNAS Early Edition Articles - Fri, 12/02/2016 - 13:58
The prefrontal cortex (PFC) plays an important role in cognitive processes, including access to consciousness. The PFC receives significant cholinergic innervation and nicotinic acetylcholine receptors (nAChRs) contribute greatly to the effects of acetylcholine signaling. Using in vivo two-photon imaging of both awake and anesthetized mice, we recorded spontaneous, ongoing neuronal...

Advice For Trump ‘Go Big – Eliminate the Energy Department’

Climate Depot - Fri, 12/02/2016 - 13:07
William O’Keefe DECEMBER 1, 2016 ENERGY The Department of Energy (DOE) traces its roots to the energy crisis of 1973, which was made worse by misguided government policy.  The Arab embargo of 1973 was short lived but it lead to a series of actions that distorted energy policy and created a bureaucracy that now, thanks [...]

Scientist asks: ‘Who is better on the science? Trump or Pope Francis? Answer: Trump

Climate Depot - Fri, 12/02/2016 - 10:18
By WILLIAM M BRIGGS Published on December 1, 2016 • 3 Comments William M Briggs Pope Francis has, according to Reuters‘ interpretation, placed a shot across the bows of USS Trump when he “urged national leaders on Monday to implement global environmental agreements without delay.” The Pope did not mention the president-elect by name, but was speaking [...]

‘The climate scam corruption metastasizes’

Climate Depot - Fri, 12/02/2016 - 10:10
The problem with a giant con game like global warming hysteria is that the baseline dishonesty ends up corrupting other institutions.  Academia is pre-eminent among the collateral corruptees, but even a Native American tribe in genuine peril is in on the game.  Willis Eschenbach provides the ugly details at Watts Up With That? He spotted [...]

Russia and Brazil plan irradiation centre

World Nuclear News - Fri, 12/02/2016 - 10:09
United Innovation Corporation, a subsidiary of Russian state nuclear corporation Rosatom, has signed a memorandum of understanding with Brazilian consultancy CK3 for the development, construction and operation of an irradiation centre in Brazil. The document was signed by the director-generals of the two companies, respectively, Denis Cherednichenko and Renato Cherkezian.

NEW PAPER: CLIMATE SKEPTICISM IS A ‘PERVERSE’ EFFECT OF ‘ACTIVELY OPEN-MINDED THINKING’

Climate Depot - Fri, 12/02/2016 - 10:04
NEW PAPER: CLIMATE SCEPTICISM IS A ‘PERVERSE’ EFFECT OF ‘ACTIVELY OPEN-MINDED THINKING’ Date: 02/12/16 Kip Hansen, Climate Etc. Right-leaning subjects (Conservatives-Republicans) who have a better understanding of current science and math and/or can be characterized as having the personality trait of actively cultivating an open mind have less belief in the consensus version of climate [...]

Illinois passes Future Energy Jobs Bill

World Nuclear News - Fri, 12/02/2016 - 09:54
Legislators in the US state of Illinois yesterday passed a bill recognising the contribution of nuclear energy to the state's clean energy efforts and ensuring the continued operation of the state's nuclear power plants. The Future Energy Jobs Bill will also advance renewable energy and expand energy efficiency initiatives.

House Science Committee tweets link to climate skeptic article and Twitter storm ensues

Climate Depot - Fri, 12/02/2016 - 09:52
tweet sent by the House Science Committee has caused an Internet meltdown and even drew the ire of Bernie Sanders. Bernie Sanders speaking at town hall event. Gage Skidmore (Wikimedia) When the House’s Committee on Science sent out a tweet yesterday linking to a “Breitbart” article that called into question global warming orthodoxy, the backlash [...]

UK nuclear industry looks back at 'momentous' year

World Nuclear News - Fri, 12/02/2016 - 08:54
With the final investment decision to build the Hinkley Point C nuclear power plant in Somerset, together with progress in other planned new nuclear projects, 2016 has been a "momentous" year for the UK, delegates at the Nuclear Industry Association's Nuclear2016 conference in London heard yesterday.

Gore Lectures SUNDANCE film festival With VR ‘Global Warming’

Climate Depot - Thu, 12/01/2016 - 15:50
Featuring former Vice-President and An Inconvenient Truth star Al Gore, Melting Iceaims to take winter coat wearing SFF attendees up close to the consequences of climate change while Zero Days VR goes into the heart of America and Israel’s Stuxnet-led cyberwar with Iran. Those two very different projects will join 20 other VR and augmented reality experiences, [...]

New EPA rules push regulatory costs past $1 trillion, $3,080 per person

Climate Depot - Thu, 12/01/2016 - 15:45
The new implementation of EPA rules on heavy trucks has boosted the 10-year regulatory burden on America past $1 trillion, 75 percent of which have been imposed by the Obama administration. That amounts to a one-time charge of $3,080 per person, or an annual cost of $540, according to a new analysis from American Action [...]

Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium [Biochemistry]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using 13C metabolic flux analysis in human RPE cells, we found that RPE has an exceptionally high capacity for reductive carboxylation, a metabolic pathway...

Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis [Systems Biology]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
The model cyanobacterium, Synechococcus elongatus PCC 7942, is a genetically tractable obligate phototroph that is being developed for the bioproduction of high-value chemicals. Genome-scale models (GEMs) have been successfully used to assess and engineer cellular metabolism; however, GEMs of phototrophic metabolism have been limited by the lack of experimental datasets...

Unfolding large-scale online collaborative human dynamics [Applied Physical Sciences]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
Large-scale interacting human activities underlie all social and economic phenomena, but quantitative understanding of regular patterns and mechanism is very challenging and still rare. Self-organized online collaborative activities with a precise record of event timing provide unprecedented opportunity. Our empirical analysis of the history of millions of updates in Wikipedia...

Distinct cortical and striatal actions of a {beta}-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties [Neuroscience]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunction. In this study, we investigate the potential for newly developed β-arrestin2 (βarr2)-biased D2R...

Siderophore-based microbial adaptations to iron scarcity across the eastern Pacific Ocean [Environmental Sciences]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
Nearly all iron dissolved in the ocean is complexed by strong organic ligands of unknown composition. The effect of ligand composition on microbial iron acquisition is poorly understood, but amendment experiments using model ligands show they can facilitate or impede iron uptake depending on their identity. Here we show that...

Structural insights into the LCIB protein family reveals a new group of {beta}-carbonic anhydrases [Biochemistry]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
Aquatic microalgae have evolved diverse CO2-concentrating mechanisms (CCMs) to saturate the carboxylase with its substrate, to compensate for the slow kinetics and competing oxygenation reaction of the key photosynthetic CO2-fixing enzyme rubisco. The limiting CO2-inducible B protein (LCIB) is known to be essential for CCM function in Chlamydomonas reinhardtii. To...

Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes [Microbiology]

PNAS Early Edition Articles - Thu, 12/01/2016 - 14:26
The gut microbiota impacts many aspects of host biology including immune function. One hypothesis is that microbial communities induce epigenetic changes with accompanying alterations in chromatin accessibility, providing a mechanism that allows a community to have sustained host effects even in the face of its structural or functional variation. We...

New Paper: Global Warming ‘Pause’ May Last Until 2030

Climate Depot - Thu, 12/01/2016 - 10:02
“We estimate that the warming slowdown (< 0.1 K/decade trend beginning in 1998) could persist, due to internal variability cooling, through 2020, 2025 or 2030 with probabilities 16%, 11%, and 6%, respectively.” – Knutson et al. A new paper by Tom Knutson, Rong Zhang and Larry Horowitz of NOAA GFDL has just been published in Nature [...]

UK launches nuclear skills Strategic Plan

World Nuclear News - Thu, 12/01/2016 - 09:49
The Nuclear Skills Strategy Group (NSSG) today launched its Nuclear Skills Strategic Plan to ensure UK nuclear employers can "recruit skilled people at the required rate to meet the sector's ambitious forward program". The Strategic Plan was launched at Nuclear 2016, the Nuclear Industry Association’s annual conference in London.
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