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Intracranial chemotherapy for brain metastases [Engineering]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Metastases represent the most common brain tumors in adults. Surgical resection alone results in 45% recurrence and is usually accompanied by radiation and chemotherapy. Adequate chemotherapy delivery to the CNS is hindered by the blood–brain barrier. Efforts at delivering chemotherapy locally to gliomas have shown modest increases in survival, likely...

Algorithms, complexity, and the sciences [Evolution]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Algorithms, perhaps together with Moore’s law, compose the engine of the information technology revolution, whereas complexity—the antithesis of algorithms—is one of the deepest realms of mathematical investigation. After introducing the basic concepts of algorithms and complexity, and the fundamental complexity classes P (polynomial time) and NP (nondeterministic polynomial time, or...

Structure of a quality control complex [Biophysics and Computational Biology]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
All organisms have evolved mechanisms to manage the stalling of ribosomes upon translation of aberrant mRNA. In eukaryotes, the large ribosomal subunit-associated quality control complex (RQC), composed of the listerin/Ltn1 E3 ubiquitin ligase and cofactors, mediates the ubiquitylation and extraction of ribosome-stalled nascent polypeptide chains for proteasomal degradation. How RQC...

Mathematical model of sarcoidosis [Applied Mathematics]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on...

Chemotaxis signaling complex allosteric coupling [Biochemistry]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
Bacterial chemotaxis is mediated by signaling complexes that sense chemical gradients and direct bacteria to favorable environments by controlling a histidine kinase as a function of chemoreceptor ligand occupancy. Core signaling complexes contain two trimers of transmembrane chemoreceptor dimers, each trimer binding a coupling protein CheW and a protomer of...

Non-Fermi liquids from Goldstone modes [Physics]

PNAS Early Edition Articles - Mon, 10/27/2014 - 13:06
There are few general physical principles that protect the low-energy excitations of a quantum phase. Of these, Goldstone’s theorem and Landau–Fermi liquid theory are the most relevant to solids. We investigate the stability of the resulting gapless excitations—Nambu–Goldstone bosons (NGBs) and Landau quasiparticles—when coupled to one another, which is of...

Sendai restart now in regulator's hands

World Nuclear News - Mon, 10/27/2014 - 10:03
Japan's first reactor restart is moving to the end of the regulatory phase. Kyushu Electric Power Company has now submitted all the documentation to restart Sendai units 1 and 2 and a final decision lies with the Nuclear Regulation Authority.

Areva-Siemens updates Olkiluoto 3 arbitration claim

World Nuclear News - Mon, 10/27/2014 - 09:56
The Areva-Siemens consortium supplying the first-of-a-kind Olkiluoto 3 EPR has updated its arbitration claim against Finnish utility Teollisuuden Voima Oyj (TVO) to €3.5 billion ($4.4 billion).

First US on-site emergency equipment facility completed

World Nuclear News - Mon, 10/27/2014 - 09:03
Construction has been completed of a "beyond design" dome at Dominion's North Anna nuclear power plant in Virginia. The dome - which will house emergency equipment and supplies - is the first of its kind in the USA.

‘It’s Rarely About the Environment Anymore’

Climate Depot - Sun, 10/26/2014 - 18:34
http://townhall.com/columnists/pauldriessen/2014/10/25/its-rarely-about-the-environment-anymore-n1909581/page/full

Natural Catastrophes Drop To 10-Year Low! Weather-Related Losses Mostly Due To ‘Cold Events’

Climate Depot - Sun, 10/26/2014 - 18:06
http://notrickszone.com/2014/10/25/natural-catastrophes-drop-to-10-year-low-weather-related-losses-mostly-due-to-cold-events/

Opposite Day: Warmists now say global warming causes colder winters

Climate Depot - Sun, 10/26/2014 - 17:08
http://blogs.news.com.au/heraldsun/andrewbolt/index.php/heraldsun/comments/opposite_day_warmists_now_say_global_warming_causes_colder_winters/#195823

New paper explains how Polar Vortex is controlled by natural variability, not CO2 – Published in Climate Dynamics

Climate Depot - Sun, 10/26/2014 - 17:04
New paper explains how Polar Vortex is controlled by natural variability, not CO2 http://hockeyschtick.blogspot.com/2014/10/new-paper-explains-how-polar-vortex-is.html A paper published today in Climate Dynamics finds complex, non-linear, and chaotic interactions of natural gravity waves, the El Nino Southern Oscillation [ENSO], the solar cycle, and the Quasi-Biennial Oscillation [QBO] “combine to affect the polar vortex.” The Quasi-Biennial Oscillation [QBO] and ENSO [...]

Tom Steyer: The green billionaire pouring millions into the midterms – Has given nearly $56m

Climate Depot - Sun, 10/26/2014 - 16:29
http://www.theguardian.com/us-news/2014/oct/26/tom-steyer-green-climate-change-millions-midterms-koch

Scientist Dr. Daniel Botkin Dissents: ‘Climate Is Changing, & Some Parks Are Endangered, But Humans Aren’t The Cause’ – Rebuts Union of Concerned Scientist claims

Climate Depot - Sun, 10/26/2014 - 15:15
Botkin: I’ve done research since 1968 on the possibility of human-caused global warming and its possible ecological effects, and have published widely on this topic, discussing possible effects on biodiversity and on specific endangered species as well as on forests, cities, and historical evidence of Arctic sea ice change. I’ve also been involved in the [...]

The Unending Pause: IPCC Scientist Prof. Mojib Latif Now Sees Global Warming Pause Extending To 30 Years!

Climate Depot - Sun, 10/26/2014 - 13:04
Via The No Tricks Zone: The Unending Pause: IPCC Scientist Prof. Mojib Latif Now Sees Global Warming Pause Extending To 30 Years! By P Gosselin on 26. Oktober 2014 Leading IPCC scientist Prof Mojib Latif extends the climate warming pause to 2025. Will it ever end? From Sebastian Lüning’s and Fritz Vahrenholt’s “Die kalte Sonne” site here (translated by P Gosselin): ====================================== Not a [...]

Russia completes TVS-5 tests

World Nuclear News - Sun, 10/26/2014 - 12:47
Russia has completed testing of the TVS-5 fuel assembly containing mixed nitrides, the prototype fuel for the pilot demonstration reactor BREST-OD-300 that is to be built at the site of the Siberian Chemical Combine in Tomsk. Construction work is to start in 2016 and be completed in 2020.

UN IPCC admits new climate report all about politics! IPCC: ‘The timing is no coincidence – this is being done to be ready for Lima’ UN summit

Climate Depot - Sun, 10/26/2014 - 11:13
Related Links:  Flashback: Pre-Determined ‘Science’: IPCC at ‘beck and call’ of Govts – UN Officials Predicted Alarming Report Years Ago UN IPCC Chair Rajendra Pachauri admits purpose of UN IPCC report it to make the case that ‘action is needed on climate change’ UN IPCC chair Pachauri: ‘If the governments decide we should do things differently [...]
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