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Prediction of disease activity in models of multiple sclerosis by molecular magnetic resonance imaging of P-selectin [Neuroscience]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
New strategies for detecting disease activity in multiple sclerosis are being investigated to ameliorate diagnosis and follow-up of patients. Today, although magnetic resonance imaging (MRI) is widely used to diagnose and monitor multiple sclerosis, no imaging tools exist to predict the evolution of disease and the efficacy of therapeutic strategies....

Mechanism of H2S-mediated protection against oxidative stress in Escherichia coli [Biochemistry]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
Endogenous hydrogen sulfide (H2S) renders bacteria highly resistant to oxidative stress, but its mechanism remains poorly understood. Here, we report that 3-mercaptopyruvate sulfurtransferase (3MST) is the major source of endogenous H2S in Escherichia coli. Cellular resistance to H2O2 strongly depends on the activity of mstA, a gene that encodes 3MST....

Selective regulation of Notch ligands during angiogenesis is mediated by vimentin [Cell Biology]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
Notch signaling is a key regulator of angiogenesis, in which sprouting is regulated by an equilibrium between inhibitory Dll4-Notch signaling and promoting Jagged-Notch signaling. Whereas Fringe proteins modify Notch receptors and strengthen their activation by Dll4 ligands, other mechanisms balancing Jagged and Dll4 signaling are yet to be described. The...

Female peer mentors early in college increase women’s positive academic experiences and retention in engineering [Psychological and Cognitive Sciences]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
Scientific and engineering innovation is vital for American competitiveness, quality of life, and national security. However, too few American students, especially women, pursue these fields. Although this problem has attracted enormous attention, rigorously tested interventions outside artificial laboratory settings are quite rare. To address this gap, we conducted a longitudinal...

Healthy offspring from freeze-dried mouse spermatozoa held on the International Space Station for 9 months [Agricultural Sciences]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
If humans ever start to live permanently in space, assisted reproductive technology using preserved spermatozoa will be important for producing offspring; however, radiation on the International Space Station (ISS) is more than 100 times stronger than that on Earth, and irradiation causes DNA damage in cells and gametes. Here we...

cGAS is essential for cellular senescence [Immunology and Inflammation]

PNAS Early Edition Articles - Mon, 05/22/2017 - 12:50
Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor effects of several therapies, including radiation and chemotherapeutic drugs. Senescence also plays an important role in aging, fibrosis, and tissue repair. The DNA damage response is a key event leading to senescence, which is characterized by...

Climate Depot’s New ‘Talking Points’ Report – A-Z Debunking of Climate Claims

Climate Depot - Mon, 05/22/2017 - 12:24
Read Full report Here: http://www.cfact.org/wp-content/uploads/2017/04/Climate-Talking-Points.pdf A newly released report “How to Talk Climate Change Issues 2017” offering a virtual A-Z debunking of the climate claims heard by climate activists and the media.  Click here for full report: “How to Talk Climate Change Issues 2017” The “Talking Points Memo,” by Marc Morano of CFACT’s Climate Depot, is a complete skeptics’ guide for elected officials, media and the public [...]

Michael Mann: ‘Predictions can never be ‘falsifiable’…we must ultimately wait to see whether they come true’

Climate Depot - Mon, 05/22/2017 - 12:15
For Climategate & Penn State Professor Michael Mann’s Full article go here. Mann: “Predictions can never be ‘falsifiable’ in the present: we must ultimately wait to see whether they come true.” Climate Depot Response to Mann: “But you want so-called ‘solutions’ from the EPA and the United Nations now! And these proposed ‘solutions’ would not [...]

Analysis: Trump pulled in three directions on UN Paris climate deal as decision looms

Climate Depot - Mon, 05/22/2017 - 10:48
by Sarah Westwood After months of delays, President Trump faces a self-imposed deadline to decide the future of U.S. involvement in the Paris Climate Accords after taking stock of the deal during his first trip abroad this week. The president’s aides, his Cabinet members and foreign leaders have pulled Trump in conflicting directions on the [...]

Schwarzenegger says you can have four Hummers and still save planet

Climate Depot - Mon, 05/22/2017 - 10:39
Arnold Schwarzenegger has four Hummers and likes nothing better than getting up at 5am to ride his Harley Davidson to the beach for breakfast. Yet “The Terminator” star insists that should not stop him being an environmental evangelist. “Saving the planet is also about technology,” the former California governor told AFP, putting his foot on [...]

Trump EPA transition chief laments slow progress in killing green rules

Climate Depot - Mon, 05/22/2017 - 10:31
But his administration has frustrated some conservatives by entertaining the idea of remaining in the Paris Climate Agreement, and hesitating to tackle the Obama-era “endangerment finding” that concludes carbon dioxide is a public health threat and underlies many U.S. regulations governing emissions. Lawyers have said challenging that scientific finding could be time consuming and legally [...]

GORE SAYS TRUMP CAN’T STOP CLIMATE MOVEMENT

Climate Depot - Mon, 05/22/2017 - 10:29
CANNES, France (AP) — Al Gore says that the first four months of Donald Trump’s presidency have proven that no one person can stop the climate movement, “not even the president.” The former U.S. Vice President painted a hopeful picture for environmentalists at the Cannes Film Festival on Monday. He claimed that some U.S. states [...]

Swiss voters approve gradual nuclear phase out

World Nuclear News - Mon, 05/22/2017 - 09:26
Switzerland voted in a referendum yesterday to approve a revision to the country's energy policy that promotes the use of renewable energy sources and energy conservation. The revised Federal Energy Act also prohibits the construction of new nuclear power plants.

European consortium completes first Iter magnet

World Nuclear News - Mon, 05/22/2017 - 09:10
The first of 18 toroidal field coils has been made in Europe. Gigantic superconducting magnets, they will generate the magnetic cage to contain the Iter fusion reactor's plasma.

Geodynamics: Hot mantle rising

Nature Geoscience Advanced Online - Sun, 05/21/2017 - 23:00

Nature Geoscience. doi:10.1038/ngeo2956

Author: Oliver Shorttle

The long-term cooling of Earth's mantle is recorded in the declining temperature and volume of its volcanic outpourings over time. However, analyses of 89-million-year-old lavas from Costa Rica suggest that extremely hot mantle still lurks below.

Holocene warming in western continental Eurasia driven by glacial retreat and greenhouse forcing

Nature Geoscience Advanced Online - Sun, 05/21/2017 - 23:00

Nature Geoscience. doi:10.1038/ngeo2953

Authors: Jonathan L. Baker, Matthew S. Lachniet, Olga Chervyatsova, Yemane Asmerom & Victor J. Polyak

Detection of a persistent meteoric metal layer in the Martian atmosphere

Nature Geoscience Advanced Online - Sun, 05/21/2017 - 23:00

Nature Geoscience. doi:10.1038/ngeo2958

Authors: M. M. J. Crismani, N. M. Schneider, J. M. C. Plane, J. S. Evans, S. K. Jain, M. S. Chaffin, J. D. Carrillo-Sanchez, J. I. Deighan, R. V. Yelle, A. I. F. Stewart, W. McClintock, J. Clarke, G. M. Holsclaw, A. Stiepen, F. Montmessin & B. M. Jakosky

The hottest lavas of the Phanerozoic and the survival of deep Archaean reservoirs

Nature Geoscience Advanced Online - Sun, 05/21/2017 - 23:00

Nature Geoscience. doi:10.1038/ngeo2954

Authors: Jarek Trela, Esteban Gazel, Alexander V. Sobolev, Lowell Moore, Michael Bizimis, Brian Jicha & Valentina G. Batanova

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